Paracetamol and Atripla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Atripla (efavirenz; emtricitabine; tenofovir disoproxil fumarate). Common drug interactions include addison's disease among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Atripla. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Atripla?

Atripla has active ingredients of efavirenz; emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 36,036 Atripla users. Check the latest studies of Atripla.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

49 people who take Paracetamol and Atripla together, and have interactions are studied.

Paracetamol and Atripla drug interactions.

What are the common drug interactions of Paracetamol and Atripla, by gender? *:

female:

Addison's disease (addison's disease, a hormonal disorder disease)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Liver injury
Thrombocytopenia (decrease of platelets in blood)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Chronic kidney disease
Emotional distress

male:

Emotional distress
Anxiety
Unresponsive to stimuli
Depression
Osteonecrosis (death of bone)
Bone loss
Osteopenia (a condition where bone mineral density is lower than normal)
Tooth loss
Abdominal pain
Factor viii inhibition (suppression of factor viii)

What are the common drug interactions of Paracetamol and Atripla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hepatocellular injury (liver injury)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Lethargy (tiredness)
Quality of life decreased
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Anxiety
Emotional distress
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Renal failure (kidney dysfunction)
Bone loss
Depression
Factor viii inhibition (suppression of factor viii)
Osteonecrosis (death of bone)

40-49:

Anxiety
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Osteoporosis (bones weak and more likely to break)
Chronic kidney disease
Abdominal pain
Osteopenia (a condition where bone mineral density is lower than normal)
Upper limb fracture
Acanthosis (thickening of the skin)

50-59:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Gait disturbance
Liver injury
Mobility decreased (ability to move is reduced)
Nephropathy (damage to or disease of a kidney)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal injury (kidney injury)
Skeletal injury (bone and supporting muscle injury)

60+:

n/a

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 11 people, 22.45%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 9 people, 18.37%
Gastritis (inflammation of stomach): 7 people, 14.29%
Oesophageal Candidiasis (fungal infection of oesophagus): 6 people, 12.24%
Asthma: 5 people, 10.20%
Stress And Anxiety: 4 people, 8.16%
Hypersensitivity: 4 people, 8.16%
High Blood Pressure: 4 people, 8.16%
Depression: 4 people, 8.16%
Bacterial Infection: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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