Paracetamol and Cytotec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Cytotec (misoprostol). Common drug interactions include vomiting among females and foetal exposure during pregnancy among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Cytotec. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Cytotec?

Cytotec has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 5,812 Cytotec users. Check the latest studies of Cytotec.

On Jul, 10, 2026

81 people who take Paracetamol and Cytotec together, and have interactions are studied.

Paracetamol and Cytotec drug interactions.

What are the common drug interactions of Paracetamol and Cytotec, by gender? *:

female:

Vomiting
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Urticaria (rash of round, red welts on the skin that itch intensely)
Cardiac failure
Abdominal pain
Abortion induced (medically referred abortion)
Genital rash (rash on sex organ)
Lip swelling
Metrorrhagia (uterine bleeding at irregular intervals)
Muscle contracture (a permanent shortening of a muscle)

male:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Kidney duplex (a kidney is split into two separate collecting systems or units)
Body temperature increased
Hyperthyroidism (over activity of the thyroid gland)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Osteonecrosis (death of bone)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Rash macular (small, flat red spots)

What are the common drug interactions of Paracetamol and Cytotec, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)
Temperature regulation disorder (body is unable to maintain temperature)
Exomphalos (weakness of the baby's abdominal wall where the umbilical cord joins it)
Limb reduction defect (a birth defect in which all or some of the limbs of a foetus do not completely form while in utero)
Pulmonary artery atresia (lungs artery absent)
Talipes
Ductus arteriosus premature closure
Persistent foetal circulation (baby's blood does not need to pass by the lungs)
Right ventricular hypertrophy (right ventricular enlargement)

2-9:

n/a

10-19:

Loss of consciousness
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Vomiting

20-29:

Abortion induced (medically referred abortion)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Hydrocephalus (water on the brain)
Abnormal dreams
Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Death
Depression
Diarrhoea
Drug ineffective

30-39:

Circulatory collapse
Endometritis (inflammation of the endometrium)
Gastric haemorrhage (bleeding stomach)
Gastric ulcer perforation (stomach hole due to ulcer)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Malaise (a feeling of general discomfort or uneasiness)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pain in extremity
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

40-49:

Angioedema (rapid swelling of the dermis)
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Anuria (failure of the kidneys to produce urine)
Arthralgia (joint pain)
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
Blood alkaline phosphatase increased
Blood creatinine increased
Body temperature increased

50-59:

Erythema (redness of the skin)
Genital rash (rash on sex organ)
Lip swelling
Oedema mucosal (swelling of mucous membrane)
Rash
Rash vesicular (rash with a small bubble)
Swelling face
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Asthenia (weakness)

60+:

Abdominal pain
Erythema (redness of the skin)
Hot flush (sudden feelings of heat)
Injection site abscess
Injection site erosion
Injection site erythema (redness at injection site)
Injection site induration
Injection site pain
Injection site swelling
Night sweats (sweating in night)

What are the existing conditions these people have? *

Labor Induction: 25 people, 30.86%
Depression: 20 people, 24.69%
Abortion Induced (medically referred abortion): 17 people, 20.99%
Headache (pain in head): 15 people, 18.52%
Rickets (softening of bones): 10 people, 12.35%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 12.35%
Agitation (state of anxiety or nervous excitement): 10 people, 12.35%
Abortion Threatened (abortion with vaginal bleeding): 8 people, 9.88%
Sleep Disorder: 7 people, 8.64%
Seasonal Allergy (allergic condition due to certain season): 7 people, 8.64%

* Approximation only. Some reports may have incomplete information.

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