Paracetamol and Defitelio drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Defitelio (defibrotide sodium). Common drug interactions include cytomegalovirus enterocolitis among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Defitelio. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Defitelio?

Defitelio has active ingredients of defibrotide sodium. eHealthMe is studying from 4,343 Defitelio users. Check the latest studies of Defitelio.

On Jul, 09, 2026

19 people who take Paracetamol and Defitelio together, and have interactions are studied.

Paracetamol and Defitelio drug interactions.

What are the common drug interactions of Paracetamol and Defitelio, by gender? *:

female:

n/a

male:

Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Venoocclusive disease (small veins in the liver are obstructed)
Vomiting
Respiratory disorder (respiratory disease)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Brain stem haemorrhage (bleeding into structures of brain stem)
Diarrhoea
Disease progression

What are the common drug interactions of Paracetamol and Defitelio, by age (0-1 to 60+)? *:

0-1:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Respiratory disorder (respiratory disease)
Cytomegalovirus enterocolitis (virus infection of intestine and colon)

2-9:

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Brain stem haemorrhage (bleeding into structures of brain stem)
Diarrhoea
Disease progression
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Venoocclusive disease (small veins in the liver are obstructed)
Vomiting

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Venoocclusive Disease (small veins in the liver are obstructed): 10 people, 52.63%
Immunodeficiency Disorders: 6 people, 31.58%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 2 people, 10.53%
Bone Marrow Conditioning Regimen: 2 people, 10.53%
Urination - Excessive Volume: 1 person, 5.26%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 5.26%
Renal Disorder (kidney disease): 1 person, 5.26%
Nausea (feeling of having an urge to vomit): 1 person, 5.26%
Hypersensitivity: 1 person, 5.26%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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