Paracetamol and Estrace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Estrace (estradiol). Common drug interactions include fatigue among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Estrace. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

33 people who take Paracetamol and Estrace together, and have interactions are studied.

Paracetamol and Estrace drug interactions.

What are the common drug interactions of Paracetamol and Estrace, by gender? *:

female:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Back pain
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Urinary tract infection
Abdominal pain
Anxiety disorder
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Abdominal pain upper
Chest pain
Renal failure chronic (long lasting kidney dysfunction)
Coma (state of unconsciousness lasting more than six hours)
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Insomnia (sleeplessness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pain in extremity

What are the common drug interactions of Paracetamol and Estrace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute hepatic failure
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)

40-49:

Anxiety disorder
Depression
Insomnia (sleeplessness)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Anaphylactic reaction (serious allergic reaction)
Arthralgia (joint pain)
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chest discomfort
Chest pain

50-59:

Pruritus generalised (generalized itching)
Renal failure chronic (long lasting kidney dysfunction)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Weight increased
Drug ineffective
Abdominal pain upper
Acne (skin problems that cause pimples)
Anxiety
Arthralgia (joint pain)
Attention deficit/hyperactivity disorder

60+:

Abdominal pain
Back pain
Urinary tract infection
Arthralgia (joint pain)
Arthropathy
Asthenia (weakness)
Back injury
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiovascular disorder (heart diseases)
Diarrhoea

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 18.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 15.15%
Multiple Myeloma (cancer of the plasma cells): 5 people, 15.15%
Insomnia (sleeplessness): 3 people, 9.09%
Sleep Disorder: 2 people, 6.06%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 6.06%
Flatulence (flatus expelled through the anus): 2 people, 6.06%
Cystitis Interstitial (unknown cause characterized by bladder pain): 2 people, 6.06%
Abnormal Faeces (abnormal stool): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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