Paracetamol and Eylea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Eylea (aflibercept). Common drug interactions include arthralgia among females and fluid retention among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Eylea. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

On Jul, 23, 2026

52 people who take Paracetamol and Eylea together, and have interactions are studied.

Paracetamol and Eylea drug interactions.

What are the common drug interactions of Paracetamol and Eylea, by gender? *:

female:

Arthralgia (joint pain)
Hypotension (abnormally low blood pressure)
Lacrimation increased
Blood glucose increased
Brain neoplasm (tumour of brain)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Chronic kidney disease
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug intolerance (drug sensitivity)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)

male:

Fluid retention (an abnormal accumulation of fluid in the blood)
Pemphigoid (tense blisters on the skin)
Blindness transient (sudden loss of vision)
Confusional state
Death
Dizziness
Endophthalmitis (inflammation of the internal coats of the eye)
Pruritus (severe itching of the skin)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

What are the common drug interactions of Paracetamol and Eylea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dizziness
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

60+:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Arthralgia (joint pain)
Inflammatory marker increased
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Personality change
Urinary retention (the inability to completely or partially empty the bladder)
Vomiting
Asthenia (weakness)
Fall

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 32.69%
Age-Related Macular Degeneration: 17 people, 32.69%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 6 people, 11.54%
High Blood Cholesterol: 4 people, 7.69%
Nausea (feeling of having an urge to vomit): 3 people, 5.77%
Malignant Melanoma (skin cancer rises from melancytes): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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