Paracetamol and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Savella (milnacipran hydrochloride). Common drug interactions include acute respiratory distress syndrome among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Savella. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

12 people who take Paracetamol and Savella together, and have interactions are studied.

Paracetamol and Savella drug interactions.

What are the common drug interactions of Paracetamol and Savella, by gender? *:

female:

Acute respiratory distress syndrome
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety disorder
Arthralgia (joint pain)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)
Blood potassium decreased
Body height decreased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive

male:

Chronic kidney disease
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Paracetamol and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood potassium decreased
Disturbance in attention
Fatigue (feeling of tiredness)
Haematuria (presence of blood in urine)
Proteinuria (presence of protein in the urine)

40-49:

Acute respiratory distress syndrome
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cardiac failure congestive
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug clearance decreased
Feeding disorder (when children refuse to eat certain food groups)
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Anxiety disorder
Arthralgia (joint pain)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Foot fracture
Insomnia (sleeplessness)

60+:

Abdominal pain
Back pain
Renal impairment (severely reduced kidney function)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Body height decreased
Chronic kidney disease
Concussion (short loss of normal brain function in response to a head injury)
Joint dislocation (a joint position is changed from normal position)
Malaise (a feeling of general discomfort or uneasiness)
Nephrolithiasis (calculi in the kidneys)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 33.33%
High Blood Pressure: 3 people, 25.00%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 2 people, 16.67%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 2 people, 16.67%
Depression: 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Migraine (headache): 2 people, 16.67%
Arrhythmias (irregular heartbeat): 2 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 8.33%
Multiple Allergies (allergy to multiple agents): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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