Paracetamol and Vyvanse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Vyvanse (lisdexamfetamine dimesylate). Common drug interactions include mania among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Vyvanse. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

54 people who take Paracetamol and Vyvanse together, and have interactions are studied.

Paracetamol and Vyvanse drug interactions.

What are the common drug interactions of Paracetamol and Vyvanse, by gender? *:

female:

Mania (a state of abnormally elevated or irritable mood)
Migraine (headache)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Neuralgia (pain in one or more nerves)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paralysis
Petechiae (a small red or purple spot caused by bleeding into the skin)
Ph urine increased

male:

Anxiety
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Drug ineffective
Emotional distress
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperhidrosis (abnormally increased sweating)
Hypermetabolism (abnormal increase in the body's basal metabolic rate)
Night sweats (sweating in night)
Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell)
Osteonecrosis (death of bone)

What are the common drug interactions of Paracetamol and Vyvanse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suicidal ideation

20-29:

n/a

30-39:

Gingival bleeding (bleeding gums)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Haematocrit decreased
Haematocrit increased
Haemoglobin decreased
Haemorrhagic cerebral infarction (brain stroke with bleeding)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphocyte count decreased
Mania (a state of abnormally elevated or irritable mood)

40-49:

Anxiety
Blood pressure increased
Aspartate aminotransferase increased
Confusional state
Disturbance in attention
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperhidrosis (abnormally increased sweating)
Hypermetabolism (abnormal increase in the body's basal metabolic rate)
Night sweats (sweating in night)
Petit mal epilepsy (absence seizure)

50-59:

Anxiety
Asthenia (weakness)
Drug ineffective
Eye irritation
Eye pain
Gait disturbance
Infusion related reaction
Migraine (headache)
Myalgia (muscle pain)
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Nephrolithiasis (calculi in the kidneys)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic foot
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Knee arthroplasty
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 35 people, 64.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 27.78%
Insomnia (sleeplessness): 4 people, 7.41%
High Blood Cholesterol: 4 people, 7.41%
Bipolar Disorder (mood disorder): 4 people, 7.41%
Sleep Disorder: 3 people, 5.56%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 5.56%
Rickets (softening of bones): 3 people, 5.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.56%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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