Paroxetine and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paroxetine (paroxetine hydrochloride) and Caffeine (caffeine). Common drug interactions include depression among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Paroxetine and Caffeine. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 65,088 Paroxetine users. Check the latest studies of Paroxetine.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

42 people who take Paroxetine and Caffeine together, and have interactions are studied.

Paroxetine and Caffeine drug interactions.

What are the common drug interactions of Paroxetine and Caffeine, by gender? *:

female:

Depression
Headache (pain in head)
Drug ineffective
Anger
Autophobia (extreme dislike of oneself)
Crying
Dizziness
Hyperhidrosis (abnormally increased sweating)
Irritability
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

Completed suicide (act of taking one's own life)
Drug abuse
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Asthenia (weakness)
Blood pressure decreased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Disturbance in attention
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatitis (inflammation of the liver)

What are the common drug interactions of Paroxetine and Caffeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anger
Autophobia (extreme dislike of oneself)
Crying
Depression
Dizziness
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Irritability
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

30-39:

Completed suicide (act of taking one's own life)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Overdose
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Cardiac arrest
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Asthenia (weakness)
Blood caffeine increased

40-49:

Drug abuse
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Hyperglycaemia (high blood sugar)

50-59:

Osteoporosis (bones weak and more likely to break)
Plicated tongue
Radial nerve injury
Rash
Rectal prolapse (falling of rectum from normal place)
Restless legs syndrome (a powerful urge to move your legs)
Rosacea (a skin condition that causes facial redness)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Spinal compression fracture (fracture due to spinal compression on bone)
Ulnar nerve injury

60+:

Coronary artery bypass
Death

What are the existing conditions these people have? *

Migraine (headache): 11 people, 26.19%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.90%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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