Paroxetine and Comtan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paroxetine (paroxetine hydrochloride) and Comtan (entacapone). Common drug interactions include drug ineffective among females and cerebral haematoma among males.

The phase IV clinical study analyzes what interactions people have when they take Paroxetine and Comtan. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 65,088 Paroxetine users. Check the latest studies of Paroxetine.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

44 people who take Paroxetine and Comtan together, and have interactions are studied.

Paroxetine and Comtan drug interactions.

What are the common drug interactions of Paroxetine and Comtan, by gender? *:

female:

Drug ineffective
Injection site pain
Arrhythmia (irregular heartbeat)
Blood creatine phosphokinase increased
Blood culture positive
Blood urea increased
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dehydration (dryness resulting from the removal of water)
Depression

male:

Cerebral haematoma (collection of blood in brain)
Cerebral haemorrhage (bleeding within the brain)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Coagulopathy (blood's ability to clot is impaired)
General physical health deterioration (weak health status)
Incision site haemorrhage (bleeding from incision site)
Bleeding time prolonged
Deep brain stimulation
Pyrexia (fever)
Salivary hypersecretion (excess saliva secretion)

What are the common drug interactions of Paroxetine and Comtan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal behaviour
Affective disorder (mental disorder)
Akinesia (loss of control of voluntary muscle movements)
Drug dependence
Dyskinesia (abnormality or impairment of voluntary movement)
Dystonia (abnormal muscle tone)
Flight of ideas
Increased appetite
Insomnia (sleeplessness)
Myalgia (muscle pain)

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Dyskinesia (abnormality or impairment of voluntary movement)
Salivary hypersecretion (excess saliva secretion)

60+:

Cerebral haematoma (collection of blood in brain)
Mydriasis (a dilation of the pupil)
General physical health deterioration (weak health status)
Incision site haemorrhage (bleeding from incision site)
Bleeding time prolonged
Deep brain stimulation
Dyskinesia (abnormality or impairment of voluntary movement)
Pyrexia (fever)
Drug ineffective
Injection site pain

What are the existing conditions these people have? *

Drug Effect Decreased: 6 people, 13.64%
Depression: 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Paroxetine and Comtan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously