Paroxetine and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paroxetine (paroxetine hydrochloride) and Naprosyn (naproxen). Common drug interactions include drug withdrawal syndrome among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Paroxetine and Naprosyn. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 65,088 Paroxetine users. Check the latest studies of Paroxetine.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 10, 2026

82 people who take Paroxetine and Naprosyn together, and have interactions are studied.

Paroxetine and Naprosyn drug interactions.

What are the common drug interactions of Paroxetine and Naprosyn, by gender? *:

female:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysgeusia (disorder of the sense of taste)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glomerulonephritis chronic (long lasting group of conditions that affect parts of the kidneys called glomeruli)
Hypertension (high blood pressure)
Impaired healing
Loss of libido (loss of sexual urge)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nightmare (unpleasant dream)
Renal haematoma (blood collection in kidney)

male:

Diarrhoea
Drug ineffective
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Rash pruritic (redness with itching)
Sleep disorder
Vomiting
Adverse event
Aortic valve incompetence
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Paroxetine and Naprosyn, by age (0-1 to 60+)? *:

0-1:

Aortic valve incompetence
Bradycardia (abnormally slow heart action)
Cardiac murmur (an heart sound in valve abnormality)
Cardiomegaly (increased size of heart than normal)
Coarctation of the aorta (narrowing of the part of aorta)
Conduction disorder (serious disorder of the heart not responses proper to impulses)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Foetal macrosomia (a foetus with an excessive weight)
Heart valve incompetence (heart's valves do not work correctly)

2-9:

n/a

10-19:

n/a

20-29:

Overdose
Cholecystitis (infection of gallbladder)
Completed suicide (act of taking one's own life)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Bipolar disorder (mood disorder)
Depression
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Affective disorder (mental disorder)
Arthralgia (joint pain)
Blood cholesterol increased
Borderline personality disorder
Dysmenorrhoea (painful menstruation)
Dysthymic disorder (mild chronic depression disorder)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Constipation
Fall
Onychomycosis (fungal infection of the nail)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Abdominal pain
Anaemia (lack of blood)
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Arthralgia (joint pain)
Back injury
Brain stem stroke (rapid loss of brain function due to disturbance in the blood supply to the brain)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Haemorrhage (bleeding)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Large intestine perforation (hole in large intestine)
Leukaemia (blood or bone marrow cancer)
Loss of libido (loss of sexual urge)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nightmare (unpleasant dream)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

60+:

Arthralgia (joint pain)
Dysgeusia (disorder of the sense of taste)
Urinary tract infection
Weight decreased
Arthropathy
Diarrhoea
Haematoma (collection of blood outside the blood vessels)
Joint swelling
Myalgia (muscle pain)
Pneumonia

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 14 people, 17.07%
Depression: 14 people, 17.07%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 15.85%
Diabetes: 11 people, 13.41%
High Blood Pressure: 10 people, 12.20%
Indigestion: 9 people, 10.98%
High Blood Cholesterol: 9 people, 10.98%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 8.54%
Gout (uric acid crystals building up in the body): 6 people, 7.32%
Blood Pressure Abnormal: 6 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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