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Paxlovid and Bendamustine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Bendamustine (bendamustine). Common drug interactions include thrombocytopenia among females and progressive multifocal leukoencephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Bendamustine. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

What is Bendamustine?

Bendamustine has active ingredients of bendamustine. eHealthMe is studying from 9,508 Bendamustine users. Check the latest studies of Bendamustine.

On Jul, 29, 2026

11 people who take Paxlovid and Bendamustine together, and have interactions are studied.

Paxlovid and Bendamustine drug interactions.

What are the common drug interactions of Paxlovid and Bendamustine, by gender? *:

female:

  1. Thrombocytopenia (decrease of platelets in blood)

male:

  1. Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  2. Blindness
  3. Pain in jaw
  4. Pneumonia
  5. Skeletal injury (bone and supporting muscle injury)
  6. Drug resistance (reduction in effectiveness of a drug)
  7. Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
  8. Retinitis (inflammation of the retina in the eye)
  9. Anosmia (partial or complete loss of the sense of smell)
  10. Cholecystitis (infection of gallbladder)

What are the common drug interactions of Paxlovid and Bendamustine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  2. Blindness
  3. Drug resistance (reduction in effectiveness of a drug)
  4. Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
  5. Retinitis (inflammation of the retina in the eye)
  6. Thrombocytopenia (decrease of platelets in blood)
  7. Cholecystitis (infection of gallbladder)

What are the existing conditions these people have? *

  1. Pneumonia: 2 people, 18.18%
  2. Insomnia (sleeplessness): 2 people, 18.18%
  3. Muscle Spasms (muscle contraction): 1 person, 9.09%
  4. Immunodeficiency Disorders: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Paxlovid and Bendamustine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Paxlovid and Bendamustine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Paxlovid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Bendamustine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Paxlovid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bendamustine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nirmatrelvir; ritonavir and bendamustine (the active ingredients of Paxlovid and Bendamustine, respectively), and Paxlovid and Bendamustine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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