Paxlovid and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Modafinil (modafinil). Common drug interactions include fatigue among females and disease recurrence among males.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Modafinil. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 05, 2026

26 people who take Paxlovid and Modafinil together, and have interactions are studied.

Paxlovid and Modafinil drug interactions.

What are the common drug interactions of Paxlovid and Modafinil, by gender? *:

female:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Disease recurrence
Anosmia (partial or complete loss of the sense of smell)
Nausea (feeling of having an urge to vomit)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cough
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Diarrhoea

male:

Disease recurrence
Dyspnoea exertional (breathlessness or shortness of breath)
Balance disorder
Gait disturbance
Pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Ill-defined disorder
Muscular weakness (muscle weakness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

What are the common drug interactions of Paxlovid and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Disease recurrence

30-39:

Disease recurrence
Cough
Diarrhoea
Fatigue (feeling of tiredness)
Paranasal sinus discomfort
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)
Upper-airway cough syndrome

40-49:

Asthenia (weakness)
Anosmia (partial or complete loss of the sense of smell)
Fatigue (feeling of tiredness)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Nausea (feeling of having an urge to vomit)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Disease recurrence
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Abdominal pain upper

50-59:

Asthma
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Muscle disorder (muscle disease)
Psoriasis (immune-mediated disease that affects the skin)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

60+:

Disease recurrence
Dyspnoea exertional (breathlessness or shortness of breath)
Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Back injury
Back pain
Blood sodium decreased
Cold sweat
Confusional state

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 23.08%
Drowsiness: 3 people, 11.54%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Paxlovid and Modafinil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously