Paxlovid and Pregabalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Pregabalin (pregabalin). Common drug interactions include sleep disorder among females and disease recurrence among males.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Pregabalin. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,422 Paxlovid users. Check the latest studies of Paxlovid.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,071 Pregabalin users. Check the latest studies of Pregabalin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

91 people who take Paxlovid and Pregabalin together, and have interactions are studied.

Paxlovid and Pregabalin drug interactions.

What are the common drug interactions of Paxlovid and Pregabalin, by gender? *:

female:

Sleep disorder
Abnormal dreams
Asthenia (weakness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hallucination (an experience involving the perception of something not present)
Nightmare (unpleasant dream)
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain upper
Asthma
Back pain

male:

Disease recurrence
Blood creatine phosphokinase increased
Back pain
Blood albumin decreased
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eye pain
Pruritus (severe itching of the skin)
Rash papulosquamous (a condition which presents with both papules and scales, or both scaly papules and plaques)
Renal pain (kidney pain)
Aphasia (damage to the parts of the brain that control language)

What are the common drug interactions of Paxlovid and Pregabalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Urinary tract infection

20-29:

n/a

30-39:

Drug ineffective
Dysgeusia (disorder of the sense of taste)
Headache (pain in head)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Disease recurrence
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Throat tightness
Cellulitis (infection under the skin)
Retching (strong involuntary effort to vomit)
Rotator cuff repair
Sleep disorder
Chest discomfort
Bradycardia (abnormally slow heart action)

50-59:

Chest discomfort
Decreased appetite
Drug ineffective
Dyspepsia (indigestion)
General physical health deterioration (weak health status)
Leukocytosis (increased white blood cells)
Leukopenia (less number of white blood cells in blood)
Loss of consciousness
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

60+:

Disease recurrence
Blood creatine phosphokinase increased
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Inflammation
Myelosuppression (a decrease in the production of blood cells)
Pruritus (severe itching of the skin)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Blood albumin decreased
Blood pressure decreased

What are the existing conditions these people have? *

Neuralgia (pain in one or more nerves): 10 people, 10.99%
Pain: 8 people, 8.79%
Neuropathy Peripheral (surface nerve damage): 8 people, 8.79%
High Blood Pressure: 7 people, 7.69%
Depression: 7 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 5.49%
High Blood Cholesterol: 5 people, 5.49%
Diabetes: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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