Paxlovid and Primidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Primidone (primidone). Common drug interactions include drug hypersensitivity among females and disease recurrence among males.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Primidone. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

On Jul, 27, 2026

14 people who take Paxlovid and Primidone together, and have interactions are studied.

Paxlovid and Primidone drug interactions.

What are the common drug interactions of Paxlovid and Primidone, by gender? *:

female:

Drug hypersensitivity
Fall
Feeling hot
Hypoaesthesia (reduced sense of touch or sensation)
Migraine (headache)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain
Pain in extremity
Pruritus (severe itching of the skin)
Sensory disturbance (sense disturbance)

male:

Disease recurrence
Abdominal pain upper
Blood glucose decreased
Decreased appetite
Diarrhoea
Dysgeusia (disorder of the sense of taste)
Hypertension (high blood pressure)
Vision blurred

What are the common drug interactions of Paxlovid and Primidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity
Feeling hot
Pruritus (severe itching of the skin)
Sensory disturbance (sense disturbance)
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

n/a

50-59:

n/a

60+:

Diarrhoea
Disease recurrence
Stomatitis (inflammation of mucous membrane of mouth)
Vision blurred
Vomiting
Abdominal pain upper
Ageusia (loss of taste functions of the tongue)
Blood pressure increased
Chills (felling of cold)
Decreased appetite

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 14.29%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 7.14%
Neuropathy Peripheral (surface nerve damage): 1 person, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.14%
Migraine (headache): 1 person, 7.14%
Meniere's Disease (a disorder of the inner ear that can affect hearing and balance to a varying degree): 1 person, 7.14%
Diabetes: 1 person, 7.14%
Depression: 1 person, 7.14%
Asthma: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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