Paxlovid and Unithroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Unithroid (levothyroxine sodium). Common drug interactions include disease recurrence among females and disease recurrence among males.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Unithroid. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

What is Unithroid?

Unithroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 890 Unithroid users. Check the latest studies of Unithroid.

On Jul, 16, 2026

18 people who take Paxlovid and Unithroid together, and have interactions are studied.

Paxlovid and Unithroid drug interactions.

What are the common drug interactions of Paxlovid and Unithroid, by gender? *:

female:

Disease recurrence
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Oral candidiasis (fungal infection of mouth)

male:

Disease recurrence

What are the common drug interactions of Paxlovid and Unithroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Disease recurrence
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Headache (pain in head)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oropharyngeal pain
Visual impairment

60+:

Disease recurrence
Dysgeusia (disorder of the sense of taste)
Nausea (feeling of having an urge to vomit)
Oral candidiasis (fungal infection of mouth)
Oxygen saturation increased
Tongue blistering
Tooth disorder (tooth disease)
Decreased appetite
Diarrhoea
Protein total increased

What are the existing conditions these people have? *

Thyroid Diseases: 2 people, 11.11%
Asthma: 2 people, 11.11%
Prostatomegaly (enlargement of the prostate): 1 person, 5.56%
High Blood Cholesterol: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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