Pegasys and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pegasys (peginterferon alfa 2a) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include pain in extremity among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Pegasys and Hydramine. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Pegasys?

Pegasys has active ingredients of peginterferon alfa 2a. It is often used in hepatitis c. eHealthMe is studying from 57,446 Pegasys users. Check the latest studies of Pegasys.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 05, 2026

25 people who take Pegasys and Hydramine together, and have interactions are studied.

Pegasys and Hydramine drug interactions.

What are the common drug interactions of Pegasys and Hydramine, by gender? *:

female:

Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Platelet count decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tenderness (pain or discomfort when an affected area is touched)
Tooth disorder (tooth disease)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)

male:

Anxiety
Pruritus (severe itching of the skin)
White blood cell count decreased
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Blindness
Blood creatinine increased
Bone density decreased
Bone loss
Bone neoplasm malignant (cancer of bone)

What are the common drug interactions of Pegasys and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dry skin
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone loss
Emotional distress
Pain
Tooth loss
Asthenia (weakness)
Blood thyroid stimulating hormone decreased
Dehydration (dryness resulting from the removal of water)

40-49:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Depression
Dizziness postural
Fatigue (feeling of tiredness)
Oral infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Tooth disorder (tooth disease)

50-59:

Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blindness
Blood creatinine increased
Chronic kidney disease
Emotional distress
Hypokinesia (decreased bodily movement)
Pain

60+:

Anaemia (lack of blood)
Haemoglobin decreased
Influenza like illness
Rash macular (small, flat red spots)
Red blood cell count decreased
Respiratory tract congestion (blockage on respiratory system)
Pneumonia
Arthralgia (joint pain)
Blood bilirubin increased
Platelet count decreased

What are the existing conditions these people have? *

Hiv Infection: 4 people, 16.00%
Respiratory Tract Congestion (blockage on respiratory system): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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