Pemetrexed and Cyclophosphamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pemetrexed (pemetrexed) and Cyclophosphamide (cyclophosphamide). Common drug interactions include osteonecrosis of jaw among females and respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Pemetrexed and Cyclophosphamide. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

eHealthMe: drug outcomes in the real world

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On Aug, 22, 2026

73 people who take Pemetrexed and Cyclophosphamide together, and have interactions are studied.

Pemetrexed and Cyclophosphamide drug interactions.

What are the common drug interactions of Pemetrexed and Cyclophosphamide, by gender? *:

female:

Osteonecrosis of jaw (death of bone of jaw)
Disease progression
Malignant neoplasm progression (cancer tumour came back)
Pulmonary haemorrhage (acute bleeding from the lung)
Alveolar rhabdomyosarcoma (highly malignant tumour of striated muscle derived from primitive mesenchymal cells)
Decreased appetite
Drug ineffective
Faeces hard
Malaise (a feeling of general discomfort or uneasiness)
Metastases to lung (cancer spreads to lung)

male:

Respiratory failure (inadequate gas exchange by the respiratory system)
Drug ineffective
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pyrexia (fever)
Ataxia (loss of full control of bodily movements)
Cerebral disorder (brain disease)
Decreased appetite
Medulloblastoma recurrent (reoccurrence of a fast-growing, high-grade tumour that always begins in the cerebellum)
Spinal disorder (disease of spine a back bone)
Strabismus (a disorder in which the two eyes do not line up in the same direction)

What are the common drug interactions of Pemetrexed and Cyclophosphamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alveolar rhabdomyosarcoma (highly malignant tumour of striated muscle derived from primitive mesenchymal cells)
Ataxia (loss of full control of bodily movements)
Cerebral disorder (brain disease)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Decreased appetite
Malignant neoplasm progression (cancer tumour came back)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Medulloblastoma recurrent (reoccurrence of a fast-growing, high-grade tumour that always begins in the cerebellum)
Nausea (feeling of having an urge to vomit)
Spinal disorder (disease of spine a back bone)

10-19:

Alveolar rhabdomyosarcoma (highly malignant tumour of striated muscle derived from primitive mesenchymal cells)
Disease progression
Disease recurrence
Intestinal perforation (complete penetration of the wall of the intestine)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)

20-29:

n/a

30-39:

Pulmonary haemorrhage (acute bleeding from the lung)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary mass
Hypertension (high blood pressure)

40-49:

Hydrocephalus (water on the brain)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Metastases to bone (cancer spreads to bone)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to kidney (cancer spreads to kidney)
Metastases to lung (cancer spreads to lung)
Neoplasm progression (growth of tumour)

50-59:

Drug ineffective
Peripheral t-cell lymphoma unspecified stage iv (peripheral t-cell cancer unspecified stage iv)
Ascites (accumulation of fluid in the abdominal cavity)
Death
Disease progression
Drug intolerance (drug sensitivity)
Malignant neoplasm progression (cancer tumour came back)

60+:

Osteonecrosis of jaw (death of bone of jaw)
Disease progression
Myelosuppression (a decrease in the production of blood cells)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pyrexia (fever)
Decreased appetite
Faeces hard
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)
Ovarian epithelial cancer (cancer that begins in the cells on the surface of the ovary)

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 11 people, 15.07%
Osteoporosis (bones weak and more likely to break): 8 people, 10.96%
Metastases To Lung (cancer spreads to lung): 8 people, 10.96%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 8 people, 10.96%
Metastases To Bone (cancer spreads to bone): 7 people, 9.59%
Breast Cancer: 7 people, 9.59%
Lung Cancer - Non-Small Cell (lung cancer): 6 people, 8.22%
Angioimmunoblastic T-Cell Lymphoma (mature t-cell cancer of the blood or lymph vessel): 5 people, 6.85%
Thymoma (a tumour originating from the epithelial cells of the thymus): 4 people, 5.48%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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