Penicillin and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Penicillin (penicillin g potassium) and Actos (pioglitazone hydrochloride). Common drug interactions include diastolic dysfunction among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Penicillin and Actos. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

28 people who take Penicillin and Actos together, and have interactions are studied.

What are the common drug interactions of Penicillin and Actos, by gender? *:

female:

Diastolic dysfunction
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness
Drug hypersensitivity
Dry skin
Dysgeusia (disorder of the sense of taste)
Dyslipidaemia (abnormal amount of lipids)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Asthenia (weakness)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood glucose increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure

What are the common drug interactions of Penicillin and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Anxiety
Nephropathy (damage to or disease of a kidney)
Renal injury (kidney injury)

50-59:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperkalaemia (damage to or disease of the kidney)
Hyperkeratosis (thickening of the outer layer of the skin)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Blood glucose increased
Cardiac failure
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 60.71%
Pain: 16 people, 57.14%
High Blood Cholesterol: 14 people, 50.00%
Infection: 8 people, 28.57%
High Blood Pressure: 7 people, 25.00%
Blood Pressure Abnormal: 6 people, 21.43%
Cardiac Disorder: 5 people, 17.86%
Cardiac Failure: 4 people, 14.29%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 14.29%
Gout (uric acid crystals building up in the body): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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