Pennsaid and Fetzima drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pennsaid (diclofenac sodium) and Fetzima (levomilnacipran hydrochloride). Common drug interactions include fatigue among females and acne among males.

The phase IV clinical study analyzes what interactions people have when they take Pennsaid and Fetzima. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

On Jul, 09, 2026

22 people who take Pennsaid and Fetzima together, and have interactions are studied.

What are the common drug interactions of Pennsaid and Fetzima, by gender? *:

female:

Fatigue (feeling of tiredness)
Suicidal ideation
Borderline personality disorder
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Sleep attacks
Victim of abuse
Bedridden
Memory impairment
Adjustment disorder with depressed mood

male:

Acne (skin problems that cause pimples)
Chest pain
Blood cholesterol increased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Anxiety
Back disorder
Balance disorder
Dizziness
Enuresis (repeated inability to control urination)
Eructation (release of gas from the digestive tract)

What are the common drug interactions of Pennsaid and Fetzima, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Borderline personality disorder
Fatigue (feeling of tiredness)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Sleep attacks
Suicidal ideation
Victim of abuse
Bedridden
Blood cholesterol increased
Memory impairment

30-39:

Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress
Therapeutic response unexpected

40-49:

n/a

50-59:

n/a

60+:

Acne (skin problems that cause pimples)
Chest pain
Swelling
Neuropathy peripheral (surface nerve damage)
Pain in extremity
Blood pressure increased
Cataract (clouding of the lens inside the eye)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Foot fracture
Peripheral swelling

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 72.73%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 18.18%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 18.18%
Drowsiness: 2 people, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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