Pennsaid and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pennsaid (diclofenac sodium) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include weight decreased among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Pennsaid and Hydroxyzine. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 11, 2026

40 people who take Pennsaid and Hydroxyzine together, and have interactions are studied.

Pennsaid and Hydroxyzine drug interactions.

What are the common drug interactions of Pennsaid and Hydroxyzine, by gender? *:

female:

Weight decreased
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Pain in extremity
Renal failure (kidney dysfunction)
Abdominal pain upper
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug effect decreased

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Gastric cancer (stomach cancer)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)

What are the common drug interactions of Pennsaid and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Headache (pain in head)
Oropharyngeal pain
Rash
Respiratory tract infection
Sinus disorder (disease of sinus)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

50-59:

Respiratory tract congestion (blockage on respiratory system)
Sinusitis (inflammation of sinus)
Thyroxine free increased
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight increased
Arthralgia (joint pain)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain
Pain in extremity

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dry throat
Gastric cancer (stomach cancer)
Influenza like illness
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Back pain
Death

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 27.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 22.50%
Pain: 8 people, 20.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 17.50%
Gastric Ulcer (stomach ulcer): 6 people, 15.00%
Irritable Bowel Syndrome: 5 people, 12.50%
High Blood Pressure: 5 people, 12.50%
Asthma: 5 people, 12.50%
Muscle Spasms (muscle contraction): 5 people, 12.50%
Cushing's Syndrome (obesity, a rounded face, increased fat): 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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