Pennsaid and Lantus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pennsaid (diclofenac sodium) and Lantus (insulin glargine recombinant). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Pennsaid and Lantus. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.

On Jul, 07, 2026

29 people who take Pennsaid and Lantus together, and have interactions are studied.

What are the common drug interactions of Pennsaid and Lantus, by gender? *:

female:

Chronic kidney disease
Gastric ulcer (stomach ulcer)
Renal failure (kidney dysfunction)
Suicidal ideation
Muscle spasms (muscle contraction)
Pruritus (severe itching of the skin)
Application site dryness
Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface)
Diarrhoea
Nephrolithiasis (calculi in the kidneys)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Dyspepsia (indigestion)
Nephrogenic anaemia (anaemia due to kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Drug ineffective
Gastrointestinal arteriovenous malformation (malformation of arteries and veins in gastrointestinal tract)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)

What are the common drug interactions of Pennsaid and Lantus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Gastric ulcer (stomach ulcer)
Suicidal ideation
Dyspepsia (indigestion)
Nephrogenic anaemia (anaemia due to kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Muscle spasms (muscle contraction)
Pruritus (severe itching of the skin)
Abdominal pain
Altered state of consciousness (altered state of mind)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Back pain
Blood glucose increased
Cellulitis (infection under the skin)
Chest pain
Chronic kidney disease

What are the existing conditions these people have? *

Pain: 9 people, 31.03%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 27.59%
High Blood Cholesterol: 8 people, 27.59%
Asthma: 7 people, 24.14%
Itching: 5 people, 17.24%
Inflammation: 4 people, 13.79%
Bone Disorder: 4 people, 13.79%
Depression: 4 people, 13.79%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 13.79%
Gastric Ulcer (stomach ulcer): 4 people, 13.79%

* Approximation only. Some reports may have incomplete information.

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