Pennsaid and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pennsaid (diclofenac sodium) and Oxycodone (oxycodone hydrochloride). Common drug interactions include blister among females and joint dislocation among males.

The phase IV clinical study analyzes what interactions people have when they take Pennsaid and Oxycodone. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Jul, 13, 2026

52 people who take Pennsaid and Oxycodone together, and have interactions are studied.

Pennsaid and Oxycodone drug interactions.

What are the common drug interactions of Pennsaid and Oxycodone, by gender? *:

female:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Discomfort
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Hepatic enzyme increased
Hypersensitivity
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Abdominal pain
Altered state of consciousness (altered state of mind)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Bipolar disorder (mood disorder)

male:

Joint dislocation (a joint position is changed from normal position)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypertension (high blood pressure)
Impaired fasting glucose
Intervertebral disc degeneration (spinal disc degeneration)
Iritis (painful inflammation of the iris of the eye)
Pulmonary sarcoidosis (growth of tiny collections of inflammatory cells in lungs)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Small intestinal obstruction (blockage in small intestine)

What are the common drug interactions of Pennsaid and Oxycodone, by age (0-1 to 60+)? *:

0-1:

Acquired immunodeficiency syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv))
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Critical illness polyneuropathy
Decreased immune responsiveness
Fall
Finger deformity (a deformed position of the finger)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gait disturbance

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Discomfort
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Hepatic enzyme increased
Hypersensitivity
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Bipolar disorder (mood disorder)
Chest pain
Chronic kidney disease

50-59:

Actinic keratosis (skin disease due to sun exposure)
Aortic dilatation
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Fracture displacement
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypertension (high blood pressure)
Impaired fasting glucose

60+:

Drug dependence
Pruritus (severe itching of the skin)
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Abdominal pain
Altered state of consciousness (altered state of mind)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Application site reaction
Asthenia (weakness)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 15.38%
Nausea (feeling of having an urge to vomit): 6 people, 11.54%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 11.54%
Stress And Anxiety: 5 people, 9.62%
Migraine (headache): 4 people, 7.69%
Insomnia (sleeplessness): 4 people, 7.69%
Multiple Allergies (allergy to multiple agents): 3 people, 5.77%
Malaria (a parasitic disease due to mosquito bite): 3 people, 5.77%
Itching: 3 people, 5.77%
Irritable Bowel Syndrome: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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