Pentasa and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentasa (mesalamine) and Arava (leflunomide). Common drug interactions include asthenia among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Pentasa and Arava. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Jul, 17, 2026

23 people who take Pentasa and Arava together, and have interactions are studied.

What are the common drug interactions of Pentasa and Arava, by gender? *:

female:

Asthenia (weakness)
Drug ineffective
Fatigue (feeling of tiredness)
Adverse event
Adverse reaction
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rash
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

male:

Back pain
Diarrhoea
Loss of consciousness
Metastases to spine (cancer spreads to spine)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Speech disorder
Spinal disorder (disease of spine a back bone)
Epiduritis (inflammatory diseases of the spinal cord)
Ileal ulcer
Oesophageal ulcer (ulcer of oesophagus)

What are the common drug interactions of Pentasa and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Diarrhoea
Drug ineffective
Feeling drunk
Herpes zoster
Insomnia (sleeplessness)
Melanosis (a disorder of pigmentation of the wall of the colon)
Muscle spasms (muscle contraction)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

50-59:

n/a

60+:

Adverse event
Adverse reaction
Drug level decreased
Fatigue (feeling of tiredness)
Heart rate decreased
Hepatic enzyme increased
Joint swelling
Multiple allergies (allergy to multiple agents)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 47.83%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 47.83%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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