Pentasa and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentasa (mesalamine) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include disseminated intravascular coagulation among females and pancytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Pentasa and Cotrim. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

On Jul, 19, 2026

19 people who take Pentasa and Cotrim together, and have interactions are studied.

What are the common drug interactions of Pentasa and Cotrim, by gender? *:

female:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Gastroenteritis (inflammation of stomach and intestine)
Renal disorder (kidney disease)

male:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Calculus urinary (stone in urinary system)
Death
Depression
Diarrhoea
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional distress
Erythema multiforme (a type of hypersensitivity reaction)
Fall

What are the common drug interactions of Pentasa and Cotrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Blood cholesterol increased
Depression
Emotional distress
Inflammatory bowel disease
Irritable bowel syndrome
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Suicidal ideation

20-29:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Pneumonia primary atypical (primary atypical pneumonia which were probably caused by mycoplasma pneumoniae)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

30-39:

Headache (pain in head)
Renal disorder (kidney disease)

40-49:

Erythema multiforme (a type of hypersensitivity reaction)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Intraocular pressure increased
Oral discomfort (pain or irritation in mouth)
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Renal disorder (kidney disease)
Acquired claw toe (acquired musculoskeletal deformities)
Cholecystitis acute (rapid infection of gallbladder)
Diarrhoea
Haematemesis (vomiting of blood)
Haematuria (presence of blood in urine)
Mouth haemorrhage (bleeding from mouth)
Platelet count decreased
Serum ferritin increased

60+:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Gastroenteritis (inflammation of stomach and intestine)
Kidney transplant rejection
Left ventricular failure (left ventricle fails to contract forcefully)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Renal failure acute (rapid kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 10 people, 52.63%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Inflammatory Bowel Disease: 2 people, 10.53%
Hypokalemia (low potassium): 1 person, 5.26%
Behcet's Syndrome (involves inflammation of the blood vessels): 1 person, 5.26%
Conjunctivitis Allergic (inflammation of the conjunctiva due to allergy): 1 person, 5.26%
Diarrhea: 1 person, 5.26%
Enlarged Prostate: 1 person, 5.26%
Erythema Multiforme (a type of hypersensitivity reaction): 1 person, 5.26%
Headache (pain in head): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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