Pentasa and Levoxyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentasa (mesalamine) and Levoxyl (levothyroxine sodium). Common drug interactions include mitral valve incompetence among females and hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Pentasa and Levoxyl. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

On Jul, 13, 2026

26 people who take Pentasa and Levoxyl together, and have interactions are studied.

What are the common drug interactions of Pentasa and Levoxyl, by gender? *:

female:

Mitral valve incompetence (inefficient heart valve)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Headache (pain in head)
Diarrhoea
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Pain
Vomiting
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)

male:

Hypersensitivity
Infusion related reaction
Myalgia (muscle pain)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Rash
Small intestinal stenosis (abnormal narrowing of small intestine)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Rash pruritic (redness with itching)
Anaphylactic reaction (serious allergic reaction)

What are the common drug interactions of Pentasa and Levoxyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypersensitivity
Infusion related reaction
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Small intestinal stenosis (abnormal narrowing of small intestine)

20-29:

n/a

30-39:

Infusion related reaction
Upper respiratory tract infection

40-49:

Headache (pain in head)
Abdominal pain
Alopecia (absence of hair from areas of the body)
Diarrhoea
Migraine (headache)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Vision blurred

50-59:

Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypokalaemia (low potassium)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Pain
Pre-existing disease
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Small intestinal stenosis (abnormal narrowing of small intestine)
Tooth disorder (tooth disease)
Vomiting

60+:

Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Injection site haemorrhage (bleeding from injection site)
Dyspepsia (indigestion)
Abscess (pus)
Anaemia of chronic disease
Anticonvulsant drug level increased
Anxiety
Asthenia (weakness)
Back pain
Balance disorder

What are the existing conditions these people have? *

Thyroid Diseases: 11 people, 42.31%
Pain: 4 people, 15.38%
Hypersensitivity: 3 people, 11.54%
High Blood Pressure: 3 people, 11.54%
Pneumonia: 2 people, 7.69%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 7.69%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 7.69%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 7.69%
Diabetes: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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