Pentoxifylline and Dapsone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentoxifylline (pentoxifylline) and Dapsone (dapsone). Common drug interactions include cellulitis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Pentoxifylline and Dapsone. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,732 Dapsone users. Check the latest studies of Dapsone.

On Jul, 16, 2026

49 people who take Pentoxifylline and Dapsone together, and have interactions are studied.

Pentoxifylline and Dapsone drug interactions.

What are the common drug interactions of Pentoxifylline and Dapsone, by gender? *:

female:

Cellulitis (infection under the skin)
Klebsiella infection
Osteonecrosis (death of bone)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Sepsis (a severe blood infection that can lead to organ failure and death)
Drug ineffective
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Renal failure (kidney dysfunction)
Mouth ulceration (mouth ulcers)
Neutropenia (an abnormally low number of neutrophils)

male:

Abdominal pain
Diabetes mellitus inadequate control
Alpha tumour necrosis factor increased
Anaemia (lack of blood)
Disease progression
Erythema (redness of the skin)
Interleukin level increased
Lymphadenitis (inflammation or enlargement of a lymph node)
Lymphadenopathy (disease or enlargement of lymph nodes)
Myalgia (muscle pain)

What are the common drug interactions of Pentoxifylline and Dapsone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective
Genital lesion (sores, warts, or blemishes that appear on the genitals)
Haemorrhage (bleeding)
Hoarseness (changing voice)
Multi-organ failure (multisystem organ failure)
Renal failure acute (rapid kidney dysfunction)
Respiratory distress (difficulty in breathing)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Skin lesion

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Fatigue (feeling of tiredness)
Pain
Quality of life decreased
Renal failure (kidney dysfunction)
Renal transplant

40-49:

Abdominal pain
Diabetes mellitus inadequate control
Diarrhoea
Hypertriglyceridaemia (excess of triglycerides in the blood)
Oral candidiasis (fungal infection of mouth)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Anaemia (lack of blood)
Drug ineffective
Type 2 lepra reaction
Renal failure (kidney dysfunction)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Drug ineffective
Chest pain
Influenza
Neuritis (inflammation of nerve)
Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance)
Cellulitis (infection under the skin)
Klebsiella infection
Osteonecrosis (death of bone)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

60+:

Dyspnoea (difficult or laboured respiration)
Abdominal discomfort
Drug effect decreased
Drug ineffective
Staphylococcus test positive
Therapeutic response unexpected with drug substitution

What are the existing conditions these people have? *

Type 2 Lepra Reaction: 12 people, 24.49%
Pyoderma Gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance): 7 people, 14.29%
Behcet's Syndrome (involves inflammation of the blood vessels): 6 people, 12.24%
Leprosy (a disfiguring disease caused by the mycobacterium leprae bacteria): 5 people, 10.20%
Skin Plaque (red, scaly patches to appear on the skin): 3 people, 6.12%
Lepromatous Leprosy (very serious form of leprosy characterized by lesions that spread over much of the body and affecting many systems of the body): 3 people, 6.12%
Hiv Infection: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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