Pentoxifylline and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentoxifylline (pentoxifylline) and Modafinil (modafinil). Common drug interactions include hypertension among females and dihydrotestosterone increased among males.

The phase IV clinical study analyzes what interactions people have when they take Pentoxifylline and Modafinil. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 19, 2026

30 people who take Pentoxifylline and Modafinil together, and have interactions are studied.

Pentoxifylline and Modafinil drug interactions.

What are the common drug interactions of Pentoxifylline and Modafinil, by gender? *:

female:

Hypertension (high blood pressure)
Bradycardia (abnormally slow heart action)
Cough
Diplopia (double vision)
Endometrial cancer
Endometrial hyperplasia (enlargement of uterus wall)
Fatigue (feeling of tiredness)
Memory impairment
Migraine (headache)
Ulcer

male:

Dihydrotestosterone increased
Brain injury
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug hypersensitivity
Drug ineffective
Drug level decreased
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Feeling drunk

What are the common drug interactions of Pentoxifylline and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Brain injury
Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Tachyphylaxis (a medical term describing an acute (sudden) decrease in the response to a drug after its administration)
Cardiac failure congestive
Chronic kidney disease
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Hypoacusis (loss of hearing)
Retching (strong involuntary effort to vomit)

60+:

Dihydrotestosterone increased
Bradycardia (abnormally slow heart action)
Drug level decreased
Ejection fraction decreased (systolic heart failure)
Feeling drunk
Hangover
Influenza like illness
Limb discomfort (discomfort in leg)
Night sweats (sweating in night)
Oestradiol decreased

What are the existing conditions these people have? *

Insomnia (sleeplessness): 7 people, 23.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 16.67%
Nausea (feeling of having an urge to vomit): 4 people, 13.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 13.33%
Drowsiness: 3 people, 10.00%
Multiple Myeloma (cancer of the plasma cells): 3 people, 10.00%
Weight Decreased: 3 people, 10.00%
Carnitine Deficiency: 2 people, 6.67%
Gait Disturbance: 2 people, 6.67%
Asthma: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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