Pentoxifylline and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentoxifylline (pentoxifylline) and Zelnorm (tegaserod maleate). Common drug interactions include renal failure among females and cholelithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Pentoxifylline and Zelnorm. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.



On Jul, 17, 2026

24 people who take Pentoxifylline and Zelnorm together, and have interactions are studied.

Pentoxifylline and Zelnorm drug interactions.

What are the common drug interactions of Pentoxifylline and Zelnorm, by gender? *:

female:

  1. Renal failure (kidney dysfunction)
  2. Chest pain
  3. Nausea (feeling of having an urge to vomit)
  4. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  5. Abdominal pain upper
  6. Anaemia (lack of blood)
  7. Anxiety
  8. Atelectasis (partial or complete collapse of the lung)
  9. Bile duct stone
  10. Blood cholesterol increased

male:

  1. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  2. Headache (pain in head)
  3. Bone fragmentation
  4. Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
  5. Bone swelling
  6. Cardiac failure congestive
  7. Cellulitis (infection under the skin)
  8. Chest pain
  9. Dental caries
  10. Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Pentoxifylline and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Abdominal distension
  2. Asthenia (weakness)
  3. Chills (felling of cold)
  4. Constipation
  5. Flatulence (flatus expelled through the anus)
  6. Nausea (feeling of having an urge to vomit)

60+:

  1. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  2. Headache (pain in head)
  3. Bone fragmentation
  4. Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
  5. Bone swelling
  6. Cardiac failure congestive
  7. Cellulitis (infection under the skin)
  8. Chest pain
  9. Dental caries
  10. Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

  1. Trismus (reduced opening of the jaws): 16 people, 66.67%
  2. Multiple Myeloma (cancer of the plasma cells): 16 people, 66.67%
  3. Type 2 Diabetes: 4 people, 16.67%
  4. Muscle Spasms (muscle contraction): 3 people, 12.50%
  5. Multiple Allergies (allergy to multiple agents): 3 people, 12.50%
  6. Indigestion: 3 people, 12.50%
  7. High Blood Pressure: 3 people, 12.50%
  8. High Blood Cholesterol: 3 people, 12.50%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
  10. Gastric Ulcer (stomach ulcer): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Pentoxifylline and Zelnorm?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Pentoxifylline and Zelnorm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Pentoxifylline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zelnorm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pentoxifylline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zelnorm and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on pentoxifylline and tegaserod maleate (the active ingredients of Pentoxifylline and Zelnorm, respectively), and Pentoxifylline and Zelnorm (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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