Pepcid ac and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Actonel (risedronate sodium). Common drug interactions include tooth disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Actonel. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 17, 2026

24 people who take Pepcid ac and Actonel together, and have interactions are studied.

Pepcid ac and Actonel drug interactions.

What are the common drug interactions of Pepcid Ac and Actonel, by gender? *:

female:

Tooth disorder (tooth disease)
Tooth fracture
Dental caries
Nephropathy (damage to or disease of a kidney)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Periodontitis (inflammation of the tissue around the teeth)
Renal impairment (severely reduced kidney function)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Dysphagia (a condition in which swallowing is difficult or painful)
Mouth ulceration (mouth ulcers)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)

What are the common drug interactions of Pepcid Ac and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Bone density decreased
Bone atrophy (decrease in bone mass)
Dental caries
Nephropathy (damage to or disease of a kidney)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Periodontitis (inflammation of the tissue around the teeth)
Renal impairment (severely reduced kidney function)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Dysphagia (a condition in which swallowing is difficult or painful)
Open wound

What are the existing conditions these people have? *

Pain: 7 people, 29.17%
High Blood Cholesterol: 7 people, 29.17%
Asthma: 7 people, 29.17%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 29.17%
Insomnia (sleeplessness): 6 people, 25.00%
Hypersensitivity: 6 people, 25.00%
High Blood Pressure: 6 people, 25.00%
Blood Potassium Decreased: 6 people, 25.00%
Blood Pressure Abnormal: 6 people, 25.00%
Inflammation: 5 people, 20.83%

* Approximation only. Some reports may have incomplete information.

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