Pepcid ac and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Hydrocortisone (hydrocortisone). Common drug interactions include injection site swelling among females and adrenal mass among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Hydrocortisone. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 19, 2026

43 people who take Pepcid ac and Hydrocortisone together, and have interactions are studied.

Pepcid ac and Hydrocortisone drug interactions.

What are the common drug interactions of Pepcid Ac and Hydrocortisone, by gender? *:

female:

Injection site swelling
Intestinal obstruction
Intestinal perforation (complete penetration of the wall of the intestine)
Leukopenia (less number of white blood cells in blood)
Micturition disorder (disease of passing urine)
Nerve compression
Nerve injury
Neuralgia (pain in one or more nerves)
Neutropenia (an abnormally low number of neutrophils)
Onychoclasis (breaking of the nails)

male:

Adrenal mass
Arthralgia (joint pain)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Somnolence (a state of near-sleep, a strong desire for sleep)
Paraganglion neoplasm (paraganglion tumour)
Phaeochromocytoma (vascular tumour of the adrenal gland)
Renal failure (kidney dysfunction)
Poor venous access
Anaemia (lack of blood)
Ataxia (loss of full control of bodily movements)

What are the common drug interactions of Pepcid Ac and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Asthenia (weakness)
Bone pain
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Somnolence (a state of near-sleep, a strong desire for sleep)
Malaise (a feeling of general discomfort or uneasiness)
Poor venous access

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Pyrexia (fever)
Weight increased
Femur fracture
Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Chronic kidney disease
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))

50-59:

Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)

60+:

Hospitalisation
Hypotension (abnormally low blood pressure)
Dyspnoea (difficult or laboured respiration)
Hangover
Hypoacusis (loss of hearing)
Hypopnoea (decrease in the breathing rate)
Retching (strong involuntary effort to vomit)
Tendonitis (a condition that causes pain and swelling of tendons)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary retention (the inability to completely or partially empty the bladder)

What are the existing conditions these people have? *

Drowsiness: 9 people, 20.93%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 13.95%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 6 people, 13.95%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 13.95%
Pain: 5 people, 11.63%
High Blood Pressure: 4 people, 9.30%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 9.30%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 9.30%
Growth Hormone Deficiency: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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