Pepcid ac and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Keppra (levetiracetam). Common drug interactions include foetal exposure during pregnancy among females and foetal exposure during pregnancy among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Keppra. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

49 people who take Pepcid ac and Keppra together, and have interactions are studied.

What are the common drug interactions of Pepcid Ac and Keppra, by gender? *:

female:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby
Abnormal palmar/plantar creases (normal groove across the palm of the hand)
Dysmorphism (difference of body structure that is suggestive of a congenital disorder)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Nausea (feeling of having an urge to vomit)
Death
Drug ineffective
Headache (pain in head)

male:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby
Death
Fall
Pruritus (severe itching of the skin)
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)
Constipation
Dizziness
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)

What are the common drug interactions of Pepcid Ac and Keppra, by age (0-1 to 60+)? *:

0-1:

Flushing (the warm, red condition of human skin)

2-9:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby

10-19:

n/a

20-29:

Death
Coma (state of unconsciousness lasting more than six hours)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Overdose
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Traumatic intracranial haemorrhage (a bleeding in brain due to trauma)

40-49:

Nausea (feeling of having an urge to vomit)
Influenza
Wheezing (a high-pitched whistling sound made while you breath)
Death
Headache (pain in head)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)

50-59:

Abnormal palmar/plantar creases (normal groove across the palm of the hand)
Dysmorphism (difference of body structure that is suggestive of a congenital disorder)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hypotonia (low muscle tone)
Premature baby
Abdominal pain
Decreased appetite
Hyperchlorhydria (gastric acid levels are higher in stomach)
Pleural effusion (water on the lungs)
Chronic kidney disease

60+:

Chronic kidney disease
Lipase increased
Pruritus (severe itching of the skin)
Rash macular (small, flat red spots)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Urticaria (rash of round, red welts on the skin that itch intensely)
Renal failure (kidney dysfunction)
Death
Dizziness
Fall

What are the existing conditions these people have? *

Stress And Anxiety: 14 people, 28.57%
Headache (pain in head): 13 people, 26.53%
Indigestion: 11 people, 22.45%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 10 people, 20.41%
Birth Control: 10 people, 20.41%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 12.24%
Immunodeficiency Common Variable: 4 people, 8.16%
High Blood Pressure: 4 people, 8.16%
Pain: 3 people, 6.12%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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