Pepcid ac and Maxalt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Maxalt (rizatriptan benzoate). Common drug interactions include nausea among females and akathisia among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Maxalt. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

On Jul, 06, 2026

31 people who take Pepcid ac and Maxalt together, and have interactions are studied.

What are the common drug interactions of Pepcid Ac and Maxalt, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Back pain
Arthralgia (joint pain)
Depression
Dizziness
Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)
Groin pain
Headache (pain in head)

male:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Cardiac arrest
Chronic kidney disease
Dyskinesia (abnormality or impairment of voluntary movement)
Hyperkalaemia (damage to or disease of the kidney)
Insomnia (sleeplessness)
Renal failure (kidney dysfunction)

What are the common drug interactions of Pepcid Ac and Maxalt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Electrocardiogram qt prolonged

20-29:

n/a

30-39:

Abnormal behaviour
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Drug abuser
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired self-care
Incoherent (talking in a confused and unclear way)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple drug overdose

40-49:

Application site erythema (redness of the skin at application site)
Application site irritation
Application site pruritus (application site severe itching of the skin)
Application site scab (hard coating on the skin formed at application site)
Asthenia (weakness)
Cardiac arrest
Drug hypersensitivity
Hypertension (high blood pressure)
Metastases to meninges (cancer spreads to meninges)
Pruritus (severe itching of the skin)

50-59:

Panic attack
Abdominal discomfort
Chronic kidney disease
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Irritable bowel syndrome
Renal failure (kidney dysfunction)
Anxiety
Breast cancer
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

60+:

Cardiac arrest
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal tubular necrosis (death of kidney tubules)

What are the existing conditions these people have? *

Asthma: 10 people, 32.26%
Headache (pain in head): 9 people, 29.03%
Cough: 7 people, 22.58%
Constipation: 7 people, 22.58%
Allergic Rhinitis: 7 people, 22.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 16.13%
Immunodeficiency Common Variable: 5 people, 16.13%
Pain: 4 people, 12.90%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 4 people, 12.90%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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