Pepcid ac and Motrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Motrin (ibuprofen). Common drug interactions include diabetes mellitus among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Motrin. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

On Jul, 12, 2026

91 people who take Pepcid ac and Motrin together, and have interactions are studied.

What are the common drug interactions of Pepcid Ac and Motrin, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Disturbance in attention
Eosinophil count decreased
Eosinophil percentage decreased
Glossitis (infection of tongue with soreness)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hangover
Hepatitis acute
Hyperphagia (an abnormal appetite for food)
Hypertension (high blood pressure)

male:

Chronic kidney disease
Drug ineffective
Bone density decreased
Cardiac flutter (abnormal heart rhythm)
Emotional distress
Haemorrhage (bleeding)
Hepatic steatosis (fatty liver disease)
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Injection site extravasation (flow of (blood or lymph) from injection site)

What are the common drug interactions of Pepcid Ac and Motrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Gallbladder disorder
Injury
Blood triglycerides increased
Cholecystitis chronic (long lasting infection of gallbladder)
Depression
Disturbance in attention
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Irritability

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Cholecystitis acute (rapid infection of gallbladder)
Emotional distress
Gallbladder disorder
Multiple fractures
Tooth loss

40-49:

Renal failure (kidney dysfunction)
Cataract (clouding of the lens inside the eye)
Cystitis (inflammation of the wall of the bladder)
Depression
Fatigue (feeling of tiredness)
Glossitis (infection of tongue with soreness)
Kidney infection
Memory impairment
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Rash scaly

50-59:

Chronic kidney disease
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Death
Dehydration (dryness resulting from the removal of water)
Depression
Drug ineffective
Migraine (headache)
Renal failure (kidney dysfunction)
Suicidal ideation

60+:

Chronic kidney disease
Constipation
Carbon dioxide decreased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug ineffective
Haemorrhage (bleeding)
Hepatitis acute
Hypertension (high blood pressure)
Iodine allergy
Lacrimation increased

What are the existing conditions these people have? *

High Blood Pressure: 37 people, 40.66%
Infection: 16 people, 17.58%
High Blood Cholesterol: 15 people, 16.48%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 15.38%
Depression: 11 people, 12.09%
Muscle Spasms (muscle contraction): 11 people, 12.09%
Joint Pain: 10 people, 10.99%
Inflammation: 9 people, 9.89%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 9 people, 9.89%
Nausea (feeling of having an urge to vomit): 9 people, 9.89%

* Approximation only. Some reports may have incomplete information.

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