Pepcid ac and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include jaw disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Vicodin. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 17, 2026

92 people who take Pepcid ac and Vicodin together, and have interactions are studied.

Pepcid ac and Vicodin drug interactions.

What are the common drug interactions of Pepcid Ac and Vicodin, by gender? *:

female:

Jaw disorder (jaw disease)
Swelling
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vomiting
Abdominal pain
Asthenia (weakness)
Blood iron decreased
Diarrhoea
Pyrexia (fever)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Mood altered (changes in mood)
Nausea (feeling of having an urge to vomit)
Skin discolouration (change of skin colour)
Spinal pain (pain in spine)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Visual impairment
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Pepcid Ac and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abdominal pain
Anxiety
Depression
Diarrhoea
Drug ineffective
Hyperkalaemia (damage to or disease of the kidney)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain in extremity

50-59:

Migraine (headache)
Swelling
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased
Blood iron decreased
Chronic kidney disease
Hospitalisation
Blood disorder
Impaired gastric emptying
Abdominal pain

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Death
Diarrhoea
Fall
Insomnia (sleeplessness)
Pain in extremity
Pleural effusion (water on the lungs)
Pyrexia (fever)
Urinary incontinence (inability to control the flow of urine and involuntary urination)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 14.13%
High Blood Pressure: 13 people, 14.13%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.70%
Diabetes: 8 people, 8.70%
Stress And Anxiety: 7 people, 7.61%
Neuralgia (pain in one or more nerves): 7 people, 7.61%
Depression: 7 people, 7.61%
Inflammation: 6 people, 6.52%
Infection: 6 people, 6.52%
Indigestion: 6 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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