Pepcid and Ambisome drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid (famotidine) and Ambisome (amphotericin b). Common drug interactions include headache among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid and Ambisome. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

What is Ambisome?

Ambisome has active ingredients of amphotericin b. eHealthMe is studying from 7,934 Ambisome users. Check the latest studies of Ambisome.

On Jul, 12, 2026

48 people who take Pepcid and Ambisome together, and have interactions are studied.

What are the common drug interactions of Pepcid and Ambisome, by gender? *:

female:

Headache (pain in head)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Pyrexia (fever)
Respiratory disorder (respiratory disease)
Abdominal discomfort
Abdominal distension
Acute respiratory distress syndrome
Agitation (state of anxiety or nervous excitement)
Anxiety

male:

Blood creatinine increased
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Thrombosis (formation of a blood clot inside a blood vessel)
Renal tubular necrosis (death of kidney tubules)
Abdominal distension
Budd chiari syndrome (problem that results from blood clotting in the veins flowing out of the liver (hepatic veins))
Death
Electrolyte imbalance
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the common drug interactions of Pepcid and Ambisome, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

n/a

10-19:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Pancreatitis (inflammation of pancreas)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Respiratory distress (difficulty in breathing)

20-29:

Abdominal distension
Bacterial infection
Blood creatinine increased
Conjunctivitis (pink eye)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Oedema peripheral (superficial swelling)
Pneumonia
Pyrexia (fever)
Respiratory distress (difficulty in breathing)

30-39:

Cardiac failure congestive
Death
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Febrile neutropenia (fever with reduced white blood cells)
Multi-organ failure (multisystem organ failure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Neoplasm progression (growth of tumour)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Cryptococcosis (potentially fatal fungal disease)

40-49:

Therapeutic response decreased (less preventive response)
Vomiting
Purpura (purplish discoloration of the skin)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Aspergillosis (an infection caused by a fungus called aspergillus)
Cytomegalovirus colitis (an inflammation of the colon from virus)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
General physical health deterioration (weak health status)

50-59:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Atrioventricular block second degree (heart block second degree)
Budd chiari syndrome (problem that results from blood clotting in the veins flowing out of the liver (hepatic veins))
Electrolyte imbalance
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hepatorenal failure (decrease in kidney function in a person with a severe liver disorder)
Respiratory alkalosis (elevated blood ph due to excess breathing)

60+:

Diarrhoea
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Renal tubular necrosis (death of kidney tubules)
Abdominal distension
Abdominal pain
Alanine aminotransferase increased
Ascites (accumulation of fluid in the abdominal cavity)
Blood bilirubin increased
Blood culture positive

What are the existing conditions these people have? *

Gastritis (inflammation of stomach): 7 people, 14.58%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 7 people, 14.58%
Pneumonia Legionella (pneumonia caused by the bacteria legionella): 6 people, 12.50%
Nausea (feeling of having an urge to vomit): 3 people, 6.25%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.25%
Fungal Infection: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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