Midodrine hydrochloride and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midodrine hydrochloride (midodrine hydrochloride) and Pepcid (famotidine). Common drug interactions include migraine among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Midodrine hydrochloride and Pepcid. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Midodrine hydrochloride?

Midodrine hydrochloride has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 3,274 Midodrine hydrochloride users. Check the latest studies of Midodrine hydrochloride.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jun, 02, 2026

66 people who take Midodrine hydrochloride and Pepcid together, and have interactions are studied.

Midodrine hydrochloride and Pepcid drug interactions.

What are the common drug interactions of Midodrine Hydrochloride and Pepcid, by gender? *:

female:

Migraine (headache)
Asthenia (weakness)
Dizziness
Abdominal distension
Anaemia (lack of blood)
Chills (felling of cold)
Constipation
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Drug ineffective

male:

Anaemia (lack of blood)
International normalised ratio increased
Hallucination (an experience involving the perception of something not present)
Hip fracture
Mesenteric arteriosclerosis (hardening of mesenteric artery)
Multi-organ failure (multisystem organ failure)
Abdominal pain upper
Acute lung injury
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety

What are the common drug interactions of Midodrine Hydrochloride and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Chronic kidney disease
Encephalitis (inflammation of the brain)
Abdominal pain
Affective disorder (mental disorder)
Anxiety
Asthenia (weakness)
Asthma
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

40-49:

Ankle fracture
Gastric disorder (disease of stomach)
Headache (pain in head)
Impaired gastric emptying
Infusion related reaction
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Migraine (headache)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urticaria (rash of round, red welts on the skin that itch intensely)
Chronic kidney disease

50-59:

Death
Dependence
Depression
Fungal endocarditis (fungal infection of the inner layer of the heart)
Lung disorder (lung disease)
Vascular injury
Diarrhoea
Abdominal distension
Anaemia (lack of blood)
Constipation

60+:

Anaemia (lack of blood)
Chills (felling of cold)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Abdominal pain
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Decreased appetite
Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 18.18%
Immune System Disorder: 7 people, 10.61%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 7 people, 10.61%
Asthma: 6 people, 9.09%
Antibody Test Abnormal: 5 people, 7.58%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 6.06%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.06%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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