Pepcid and Pristiq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid (famotidine) and Pristiq (desvenlafaxine succinate). Common drug interactions include hereditary angioedema among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid and Pristiq. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,775 Pepcid users. Check the latest studies of Pepcid.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

47 people who take Pepcid and Pristiq together, and have interactions are studied.

What are the common drug interactions of Pepcid and Pristiq, by gender? *:

female:

Hereditary angioedema (recurrent episodes of severe swelling)
Hypersensitivity
Impaired driving ability
Influenza
Insomnia (sleeplessness)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Maternal exposure during pregnancy (use of substance during pregnancy)
Melaena (the passage of black, tarry stools)
Nasopharyngitis (inflammation of the nasopharynx)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)

male:

Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Frequent bowel movements
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Loss of consciousness
Pancreatitis (inflammation of pancreas)

What are the common drug interactions of Pepcid and Pristiq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Hereditary angioedema (recurrent episodes of severe swelling)
Maternal exposure during pregnancy (use of substance during pregnancy)

30-39:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Lip swelling
Adverse drug reaction
Cholecystitis chronic (long lasting infection of gallbladder)
Dizziness
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Headache (pain in head)
Infusion related reaction
Oxygen saturation decreased

40-49:

Anaphylactic reaction (serious allergic reaction)
Aphasia (damage to the parts of the brain that control language)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Decreased appetite
Delirium (wild excitement)
Dizziness
Dry mouth
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity

50-59:

Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Calcium deficiency (lack of calcium)
Chills (felling of cold)
Dysphagia (a condition in which swallowing is difficult or painful)
Gastric disorder (disease of stomach)
Osteoporosis (bones weak and more likely to break)
Poor quality sleep
Pyrexia (fever)
Vitamin d deficiency

60+:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Fatigue (feeling of tiredness)
Crying
Emotional disorder
Flatulence (flatus expelled through the anus)
Haemoglobin decreased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Headache (pain in head)
Hypertension (high blood pressure)
Infusion related reaction

What are the existing conditions these people have? *

Sleep Disorder: 25 people, 53.19%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 27.66%
Nausea (feeling of having an urge to vomit): 13 people, 27.66%
Muscle Spasms (muscle contraction): 13 people, 27.66%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 13 people, 27.66%
Pain: 11 people, 23.40%
High Blood Cholesterol: 11 people, 23.40%
Stress And Anxiety: 9 people, 19.15%
Sinus Disorder (disease of sinus): 9 people, 19.15%
Cardiac Disorder: 9 people, 19.15%

* Approximation only. Some reports may have incomplete information.

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