Pepcid and Vfend drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid (famotidine) and Vfend (voriconazole). Common drug interactions include graft versus host disease among females and respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid and Vfend. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

What is Vfend?

Vfend has active ingredients of voriconazole. It is often used in aspergillosis. eHealthMe is studying from 12,128 Vfend users. Check the latest studies of Vfend.

On Jul, 11, 2026

89 people who take Pepcid and Vfend together, and have interactions are studied.

What are the common drug interactions of Pepcid and Vfend, by gender? *:

female:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Decreased appetite
Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Pyrexia (fever)
Burning sensation
Dyspnoea (difficult or laboured respiration)
Parainfluenzae virus infection
Photosensitivity reaction
Sinusitis (inflammation of sinus)
Abdominal pain upper

male:

Respiratory failure (inadequate gas exchange by the respiratory system)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Pancreatitis (inflammation of pancreas)
Platelet count decreased
Tachypnoea (a condition of rapid breathing over 20 per minute)
White blood cell count decreased
Acute lymphocytic leukaemia (cancer of the white blood cells)
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Pericardial effusion (fluid around the heart)

What are the common drug interactions of Pepcid and Vfend, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

Ankle fracture
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Urinary tract infection

10-19:

Pyrexia (fever)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Diarrhoea
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Agitation (state of anxiety or nervous excitement)
Ammonia increased

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Renal failure chronic (long lasting kidney dysfunction)

40-49:

Blood pressure increased
Blood urine
Hydronephrosis (water inside the kidney)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Urinary tract obstruction

50-59:

Graft versus host disease in lung (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the lung)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Injury
Malignant neoplasm progression (cancer tumour came back)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Organ failure
Pain
Paraparesis (partial paralysis of the lower limbs)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Renal failure (kidney dysfunction)

60+:

Blood magnesium decreased
Malaise (a feeling of general discomfort or uneasiness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Burning sensation
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Parainfluenzae virus infection
Respiratory disorder (respiratory disease)
Sinusitis (inflammation of sinus)
Abdominal pain upper
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the existing conditions these people have? *

Pain: 24 people, 26.97%
Nausea (feeling of having an urge to vomit): 23 people, 25.84%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 15 people, 16.85%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 11 people, 12.36%
Indigestion: 10 people, 11.24%
Gastric Ulcer (stomach ulcer): 10 people, 11.24%
Nausea And Vomiting: 9 people, 10.11%
Hypersensitivity: 9 people, 10.11%
Insomnia (sleeplessness): 8 people, 8.99%
Constipation: 8 people, 8.99%

* Approximation only. Some reports may have incomplete information.

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