Pepcid and Xiidra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid (famotidine) and Xiidra (lifitegrast). Common drug interactions include impaired gastric emptying among females and tachycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid and Xiidra. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,775 Pepcid users. Check the latest studies of Pepcid.

What is Xiidra?

Xiidra has active ingredients of lifitegrast. eHealthMe is studying from 15,244 Xiidra users. Check the latest studies of Xiidra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

59 people who take Pepcid and Xiidra together, and have interactions are studied.

What are the common drug interactions of Pepcid and Xiidra, by gender? *:

female:

Impaired gastric emptying
Infusion related reaction
Insomnia (sleeplessness)
Instillation site pain
Instillation site reaction
Joint swelling
Lethargy (tiredness)
Limb discomfort (discomfort in leg)
Lip swelling
Low density lipoprotein increased (cholesterol increased in blood)

male:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Arthralgia (joint pain)
Visual impairment
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Constipation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug ineffective
Dry eye (lack of adequate tears)
Eructation (release of gas from the digestive tract)
Eye irritation

What are the common drug interactions of Pepcid and Xiidra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Back pain
Constipation
Drug ineffective
Dry eye (lack of adequate tears)
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)
Headache (pain in head)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)

30-39:

Pericarditis (inflammation of the pericardium)
Anaemia (lack of blood)
Connective tissue disorder (any disease that has the connective tissues of the body)
Depression
Hospitalisation
Pericardial effusion (fluid around the heart)

40-49:

Headache (pain in head)
Confusional state
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Lethargy (tiredness)
Limb discomfort (discomfort in leg)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Arthralgia (joint pain)
Blood pressure increased
Constipation
Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
White blood cell count increased
Blood cholesterol increased
Blood glucose increased
Cataract (clouding of the lens inside the eye)

60+:

Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Blood creatinine decreased
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Decreased appetite
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug hypersensitivity

What are the existing conditions these people have? *

Pain: 11 people, 18.64%
Dry Eyes (lack of adequate tears): 11 people, 18.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 16.95%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 13.56%
Drowsiness: 6 people, 10.17%
Stress And Anxiety: 3 people, 5.08%
Sleep Disorder: 3 people, 5.08%
Chronic Myelomonocytic Leukaemia (cancers of the blood-forming cells of the bone marrow): 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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