Percocet and Cosopt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Cosopt (dorzolamide hydrochloride; timolol maleate). Common drug interactions include anaemia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Cosopt. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

49 people who take Percocet and Cosopt together, and have interactions are studied.

What are the common drug interactions of Percocet and Cosopt, by gender? *:

female:

Anaemia (lack of blood)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cellulitis (infection under the skin)
Cough
Dizziness

male:

Dyspnoea (difficult or laboured respiration)
Memory impairment
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematocrit decreased
Inflammation

What are the common drug interactions of Percocet and Cosopt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Dysphoria (generalized dissatisfaction with life)
Gallbladder injury
Oropharyngeal discomfort (pain or irritation of oropharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Abscess (pus)
Anaemia (lack of blood)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood creatinine increased

60+:

Dyspnoea (difficult or laboured respiration)
Anxiety
Dehydration (dryness resulting from the removal of water)
Inflammation
Pain in extremity
Pulmonary hypertension (increase in blood pressure in the lung artery)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Oedema peripheral (superficial swelling)
Abscess (pus)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 9 people, 18.37%
Back Pain: 7 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 5 people, 10.20%
Lung Cancer - Non-Small Cell (lung cancer): 5 people, 10.20%
High Blood Pressure: 5 people, 10.20%
Anaemia (lack of blood): 5 people, 10.20%
Itching: 4 people, 8.16%
Neuralgia (pain in one or more nerves): 4 people, 8.16%
Depression: 4 people, 8.16%
Diabetes: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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