Percocet and Divalproex sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Divalproex sodium (divalproex sodium). Common drug interactions include headache among females and arthritis bacterial among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Divalproex sodium. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

81 people who take Percocet and Divalproex sodium together, and have interactions are studied.

Percocet and Divalproex sodium drug interactions.

What are the common drug interactions of Percocet and Divalproex Sodium, by gender? *:

female:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Sinusitis (inflammation of sinus)
Syncope (loss of consciousness with an inability to maintain postural tone)
Wound
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

male:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Ulcerative keratitis (ulcerative inflammation of the cornea)
Fall
Weight decreased
Atelectasis (partial or complete collapse of the lung)
Blood glucose fluctuation
Bronchial wall thickening
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetic foot
Effusion (an escape of fluid into a body cavity)

What are the common drug interactions of Percocet and Divalproex Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aspartate aminotransferase increased
Bile duct stone
Cholecystitis chronic (long lasting infection of gallbladder)
Culture urine positive
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Electrocardiogram qt prolonged
Emotional distress

30-39:

Blood glucose decreased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Delirium (wild excitement)
Diabetes mellitus inadequate control
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injury
Oedema peripheral (superficial swelling)
Pain in extremity
Pleural effusion (water on the lungs)
Psychotic disorder

40-49:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Eye disorder
Ulcerative keratitis (ulcerative inflammation of the cornea)
Anxiety
Skin ulcer
Arthropathy
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Weight decreased
Atelectasis (partial or complete collapse of the lung)
Blood glucose fluctuation

50-59:

Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Anxiety
Aspartate aminotransferase increased
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chest discomfort

60+:

Arthralgia (joint pain)
Pneumonia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Immune system disorder
Infection
Infusion site discomfort
Infusion site swelling
Ligament sprain (ligament stretched)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 25.93%
Immunodeficiency Common Variable: 11 people, 13.58%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 13.58%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 9 people, 11.11%
Asthma: 9 people, 11.11%
High Blood Pressure: 8 people, 9.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 8.64%
Depression: 6 people, 7.41%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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