Percocet and Efudex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Efudex (fluorouracil). Common drug interactions include hospitalisation among females and epistaxis among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Efudex. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

On Jul, 09, 2026

12 people who take Percocet and Efudex together, and have interactions are studied.

What are the common drug interactions of Percocet and Efudex, by gender? *:

female:

Hospitalisation
Hypoglycaemia (deficiency of glucose in the bloodstream)
Neuropathy peripheral (surface nerve damage)
Productive cough
Pulmonary mass
Surgery
Vulvovaginal pain
Alopecia (absence of hair from areas of the body)
Cholecystitis chronic (long lasting infection of gallbladder)
Haemorrhagic anaemia (anaemia due to excessive bleeding)

male:

Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blepharitis (chronic inflammation of the eyelid)
Blood pressure decreased
Breath sounds

What are the common drug interactions of Percocet and Efudex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hair disorder
Hair colour changes
Alopecia areata (patchy baldness that typically begins with rapid hair loss)
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Nausea (feeling of having an urge to vomit)
Productive cough
Alopecia (absence of hair from areas of the body)

60+:

Alcohol abuse
Anaemia (lack of blood)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blepharitis (chronic inflammation of the eyelid)
Blood pressure decreased
Breath sounds
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 25.00%
Breast Cancer Female: 3 people, 25.00%
Constipation: 2 people, 16.67%
Weight Loss: 1 person, 8.33%
Multiple Myeloma (cancer of the plasma cells): 1 person, 8.33%
Lymphoma (cancer that begins in immune system cells): 1 person, 8.33%
Gastrointestinal Carcinoma (cancer of stomach or intestine): 1 person, 8.33%
Cardiomyopathy (weakening of the heart muscle): 1 person, 8.33%
Arterial Occlusive Disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Percocet and Efudex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously