Percocet and Lonox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Lonox (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include social avoidant behaviour among females and anorexia among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Lonox. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Lonox?

Lonox has active ingredients of atropine sulfate; diphenoxylate hydrochloride. eHealthMe is studying from 376 Lonox users. Check the latest studies of Lonox.

On Jul, 06, 2026

14 people who take Percocet and Lonox together, and have interactions are studied.

What are the common drug interactions of Percocet and Lonox, by gender? *:

female:

Social avoidant behaviour (avoiding social connection a personality disorder)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Stress
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Throat tightness
Tricuspid valve incompetence (inefficient heart valve)
Type 2 diabetes mellitus
Varicose vein (veins that have become enlarged and tortuous)
Weight increased
Diarrhoea

male:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Blood creatinine increased
Vomiting
Abdominal pain
Chronic kidney disease
Gastritis (inflammation of stomach)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Oesophageal ulcer (ulcer of oesophagus)
Cytomegalovirus infection
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Percocet and Lonox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood creatine increased
Blood ph decreased
Blood urea increased
Completed suicide (act of taking one's own life)
Gastritis (inflammation of stomach)
Heart rate increased
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

50-59:

Diarrhoea
Pancreatitis (inflammation of pancreas)
Polymyalgia rheumatica (pain in many muscles)
Abdominal distension
Nausea (feeling of having an urge to vomit)
Vomiting
Accident at work
Anxiety
Aortic valve incompetence
Aortic valve sclerosis (narrowing of the aortic valve)

60+:

Abdominal pain
Anaphylactic reaction (serious allergic reaction)
Oedema peripheral (superficial swelling)
Throat tightness
Breast discomfort
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fear
Headache (pain in head)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Asthma: 1 person, 7.14%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 1 person, 7.14%
Allergic Rhinitis: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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