Percocet and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Naltrexone (naltrexone). Common drug interactions include dysuria among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Naltrexone. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.

On Jul, 30, 2026

79 people who take Percocet and Naltrexone together, and have interactions are studied.

Percocet and Naltrexone drug interactions.

What are the common drug interactions of Percocet and Naltrexone, by gender? *:

female:

Dysuria (painful or difficult urination)
Nausea (feeling of having an urge to vomit)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vomiting
Anxiety
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug dependence
Drug hypersensitivity
Headache (pain in head)

male:

Drug dependence
Tremor (trembling or shaking movements in one or more parts of your body)
Nerve injury
Ageusia (loss of taste functions of the tongue)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood creatinine increased
Cerebral disorder (brain disease)
Chills (felling of cold)

What are the common drug interactions of Percocet and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug dependence
Overdose
Ankle deformity
Anxiety
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Back injury
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Borderline personality disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

30-39:

Cellulitis (infection under the skin)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Staphylococcal abscess (pus formation due to staphylococcal bacteria)
Drug dependence
Chest pain
Death
Gastroenteritis (inflammation of stomach and intestine)
Homicidal ideation (thoughts about human killing another human)
Loss of employment
Suicidal behaviour

40-49:

Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nausea (feeling of having an urge to vomit)
Cerebral disorder (brain disease)
Chills (felling of cold)
Drug abuse
Erectile dysfunction
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis c
Hyperhidrosis (abnormally increased sweating)

50-59:

Dehydration (dryness resulting from the removal of water)
Duodenal obstruction (partial or complete obstruction of the duodenum)
Dysuria (painful or difficult urination)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Malignant neoplasm progression (cancer tumour came back)
Metastases to bone (cancer spreads to bone)
Metastases to liver (cancer spreads to liver)
Migraine (headache)
Nausea (feeling of having an urge to vomit)

60+:

Fall
Hyperhidrosis (abnormally increased sweating)
Head injury
Lower limb fracture
Renal disorder (kidney disease)
Skin haemorrhage (bleeding into skin)
Skin lesion
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Stomatitis (inflammation of mucous membrane of mouth)
Tongue discolouration (colour change of tongue)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 27 people, 34.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 21.52%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 10 people, 12.66%
Stress And Anxiety: 5 people, 6.33%
Immunodeficiency Common Variable: 5 people, 6.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 6.33%
Back Pain: 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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