Percocet and Valproic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Valproic acid (valproic acid). Common drug interactions include deep vein thrombosis among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Valproic acid. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

40 people who take Percocet and Valproic acid together, and have interactions are studied.

Percocet and Valproic acid drug interactions.

What are the common drug interactions of Percocet and Valproic Acid, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dry mouth
Dyspnoea (difficult or laboured respiration)
Head injury
Headache (pain in head)
Injury
Micturition urgency (urgency to pass the urine)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain

male:

Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Aspartate aminotransferase increased
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder
Chest discomfort
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental caries

What are the common drug interactions of Percocet and Valproic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Substance abuse

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)

40-49:

Agitation (state of anxiety or nervous excitement)
Abdominal distension
Abnormal dreams
Abnormal sleep-related event
Arrhythmia (irregular heartbeat)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial test positive
Bladder dilatation
Blood alkaline phosphatase increased
Burns fourth degree

50-59:

Palpitations (feelings or sensations that your heart is pounding or racing)
Abscess (pus)
Actinomycosis (infection that causes sores, or abscesses)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder

60+:

Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder
Chest discomfort
Completed suicide (act of taking one's own life)
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental caries

What are the existing conditions these people have? *

Depression: 5 people, 12.50%
Stress And Anxiety: 4 people, 10.00%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 4 people, 10.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 10.00%
Bipolar Disorder (mood disorder): 3 people, 7.50%
Procedural Pain: 2 people, 5.00%
Joint Pain: 2 people, 5.00%
Headache (pain in head): 2 people, 5.00%
General Anaesthesia: 2 people, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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