Percocet and Vimovo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Vimovo (esomeprazole magnesium; naproxen). Common drug interactions include infection among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Vimovo. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Vimovo?

Vimovo has active ingredients of esomeprazole magnesium; naproxen. It is often used in osteoarthritis. eHealthMe is studying from 9,608 Vimovo users. Check the latest studies of Vimovo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

73 people who take Percocet and Vimovo together, and have interactions are studied.

What are the common drug interactions of Percocet and Vimovo, by gender? *:

female:

Infection
Inflammation
Joint range of motion decreased (disease of joint movement)
Liver disorder (liver diseases)
Lung disorder (lung disease)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nodule (a growth of abnormal tissue)
Photophobia (extreme sensitivity to light)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Arthropathy
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Joint injury
Joint range of motion decreased (disease of joint movement)
Pancreatitis (inflammation of pancreas)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the common drug interactions of Percocet and Vimovo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hypertension (high blood pressure)

20-29:

Hypersensitivity
Tendonitis (a condition that causes pain and swelling of tendons)
Depression

30-39:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Anaemia (lack of blood)
Arthropathy
Blood pressure decreased
Drug hypersensitivity
Fall
Fatigue (feeling of tiredness)
Food allergy
Gastric infection (infection of stomach)
Impaired healing

40-49:

Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haemoglobin decreased
Hand deformity
Infection
Inflammation
Joint range of motion decreased (disease of joint movement)
Liver disorder (liver diseases)
Lung disorder (lung disease)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)

50-59:

Abdominal discomfort
Abdominal pain upper
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hysterectomy
Pancreatitis (inflammation of pancreas)
Therapeutic response unexpected
Vomiting
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Pulmonary embolism (blockage of the main artery of the lung)
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Bone pain
Carbohydrate antigen 125 increased
Dehydration (dryness resulting from the removal of water)
Developmental delay
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 17.81%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 16.44%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 13.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 10.96%
Ankylosing Spondylitis (type of arthritis affecting the spine): 8 people, 10.96%
Back Pain: 7 people, 9.59%
Stress And Anxiety: 6 people, 8.22%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 8.22%
High Blood Pressure: 6 people, 8.22%
Depression: 6 people, 8.22%

* Approximation only. Some reports may have incomplete information.

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