Percocet and Zestoretic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Zestoretic (hydrochlorothiazide; lisinopril). Common drug interactions include renal failure among females and peripheral swelling among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Zestoretic. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

On Jul, 10, 2026

80 people who take Percocet and Zestoretic together, and have interactions are studied.

Percocet and Zestoretic drug interactions.

What are the common drug interactions of Percocet and Zestoretic, by gender? *:

female:

Renal failure (kidney dysfunction)
Blood glucose increased
Cardiac failure congestive
Headache (pain in head)
Injection site rash
Urinary tract infection
Anaemia (lack of blood)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Fatigue (feeling of tiredness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

male:

Peripheral swelling
Upper respiratory tract infection
Diarrhoea
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Abdominal distension
Actinic keratosis (skin disease due to sun exposure)
Alanine aminotransferase increased
Fatigue (feeling of tiredness)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Haematocrit decreased

What are the common drug interactions of Percocet and Zestoretic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hyperthyroidism (over activity of the thyroid gland)
Pancreatitis (inflammation of pancreas)

30-39:

Angiopathy (generic term for a disease of the blood vessels)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic foot
Diabetic foot infection
Diabetic gangrene
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic vascular disorder (diseases of the blood vessels due to diabetes)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Necrosis (the death of body tissue)

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Abscess limb (limb infection)
Anxiety
Chest pain
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nerve injury
Perirectal abscess
Pleuritic pain

50-59:

Vitamin d deficiency
Alanine aminotransferase increased
Depression
Fatigue (feeling of tiredness)
Haematocrit decreased
Urinary tract infection
Actinic keratosis (skin disease due to sun exposure)
Cellulitis (infection under the skin)
Chills (felling of cold)
Diarrhoea

60+:

Cardiac failure congestive
Sepsis (a severe blood infection that can lead to organ failure and death)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Anaemia (lack of blood)
Anxiety
Drug hypersensitivity
Epistaxis (bleed from the nose)
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 16 people, 20.00%
Type 2 Diabetes: 15 people, 18.75%
Depression: 11 people, 13.75%
High Blood Cholesterol: 8 people, 10.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 8 people, 10.00%
Insomnia (sleeplessness): 7 people, 8.75%
Hypotension (abnormally low blood pressure): 7 people, 8.75%
Muscle Spasms (muscle contraction): 7 people, 8.75%
Nausea (feeling of having an urge to vomit): 7 people, 8.75%
Sleep Disorder: 7 people, 8.75%

* Approximation only. Some reports may have incomplete information.

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