Percodan and Vioxx drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate) and Vioxx (rofecoxib). Common drug interactions include drug ineffective among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Percodan and Vioxx. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

On Jul, 10, 2026

18 people who take Percodan and Vioxx together, and have interactions are studied.

What are the common drug interactions of Percodan and Vioxx, by gender? *:

female:

Drug ineffective
Abdominal pain
Abdominal pain lower
Anaemia (lack of blood)
Back pain
Blood in stool
Constipation
Drug hypersensitivity
Erythrocyte sedimentation rate increased
Hyperpyrexia (extremely high fever)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Renal failure chronic (long lasting kidney dysfunction)
Shoulder pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Arthropathy
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Asthenia (weakness)
Blood creatinine increased
Blood glucose increased

What are the common drug interactions of Percodan and Vioxx, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Asthenia (weakness)
Completed suicide (act of taking one's own life)
Depressed mood
Disturbance in attention
Dizziness
Headache (pain in head)
Nervousness

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Renal failure chronic (long lasting kidney dysfunction)
Shoulder pain
Blood creatinine increased
Blood glucose increased
Drug hypersensitivity
Hypoglycaemia (deficiency of glucose in the bloodstream)

50-59:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Bipolar disorder (mood disorder)
Blood pressure increased
Cardiac disorder
Constipation
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Cystitis (inflammation of the wall of the bladder)
Depression
Drug abuser
Drug dependence

60+:

Alopecia (absence of hair from areas of the body)
Drug ineffective
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Depression: 3 people, 16.67%
High Blood Pressure: 2 people, 11.11%
Sinusitis (inflammation of sinus): 1 person, 5.56%
Parkinson's Disease: 1 person, 5.56%
Jock Itch (fungal infection of the groin and upper thighs): 1 person, 5.56%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 1 person, 5.56%
Allergic Rhinitis: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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