Periactin and Claritin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Claritin (loratadine). Common drug interactions include dry skin among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Claritin. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Claritin?

Claritin has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 77,315 Claritin users. Check the latest studies of Claritin.

On Jul, 07, 2026

46 people who take Periactin and Claritin together, and have interactions are studied.

Periactin and Claritin drug interactions.

What are the common drug interactions of Periactin and Claritin, by gender? *:

female:

Dry skin
Dry throat
Dysphagia (a condition in which swallowing is difficult or painful)
Eructation (release of gas from the digestive tract)
Feeling hot
Flushing (the warm, red condition of human skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate increased
Herpes zoster
Hypertension (high blood pressure)

male:

Abnormal behaviour
Arthralgia (joint pain)
Thromboembolism (obstruction of artery by blood clot)
Upper respiratory tract infection
Abnormal dreams
Activities of daily living impaired
Acute sinusitis
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma

What are the common drug interactions of Periactin and Claritin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Asthma
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Pyrexia (fever)
Cystic fibrosis (disease of the secretary glands)
Rash papular (redness with papule)
Activities of daily living impaired
Aspergillus test positive
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation

10-19:

Abdominal pain
Appendicitis (inflammation of the appendix)
Abnormal behaviour
Arthralgia (joint pain)
Body temperature increased
Delirium (wild excitement)
Hallucination, visual (seeing things that aren't there)
Constipation
Depression
Faecal volume increased

20-29:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Constipation
Distal intestinal obstruction syndrome (blockage of the intestines by thickened stool and occurs in individuals with cystic fibrosis)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)

30-39:

Abnormal dreams
Depression
Dyspnoea (difficult or laboured respiration)
Hypophagia (reduced food intake)
Insomnia (sleeplessness)
Panic attack
Psychomotor retardation (motor mental retardation)
Weight decreased

40-49:

Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Constipation
Folliculitis (infection of hair root)
Headache (pain in head)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vision blurred
Thromboembolism (obstruction of artery by blood clot)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Oedema peripheral (superficial swelling)

60+:

Abdominal discomfort
Asthenia (weakness)
Dry eye (lack of adequate tears)
Dry skin
Dry throat
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Eructation (release of gas from the digestive tract)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 11 people, 23.91%
Asthma: 8 people, 17.39%
Constipation: 8 people, 17.39%
Wheezing (a high-pitched whistling sound made while you breath): 6 people, 13.04%
Stress And Anxiety: 6 people, 13.04%
Seasonal Allergy (allergic condition due to certain season): 5 people, 10.87%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 5 people, 10.87%
Pain: 5 people, 10.87%
Cough: 5 people, 10.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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