Periactin and Geodon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Geodon (ziprasidone hydrochloride). Common drug interactions include panic attack among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Geodon. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Geodon?

Geodon has active ingredients of ziprasidone hydrochloride. It is often used in bipolar disorder. eHealthMe is studying from 19,504 Geodon users. Check the latest studies of Geodon.

On Jul, 18, 2026

11 people who take Periactin and Geodon together, and have interactions are studied.

What are the common drug interactions of Periactin and Geodon, by gender? *:

female:

Panic attack
Anxiety
Epistaxis (bleed from the nose)
Tremor (trembling or shaking movements in one or more parts of your body)
Type 2 diabetes mellitus
Chest discomfort
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drooling (drop saliva uncontrollably from the mouth)
Malaise (a feeling of general discomfort or uneasiness)
Obesity (having too much body fat)

male:

Vomiting
Weight decreased
Influenza like illness
Nausea (feeling of having an urge to vomit)
Otitis externa (external ear infection)
Pain in jaw
Peripheral coldness
Pneumonia
Rash
Rash pruritic (redness with itching)

What are the common drug interactions of Periactin and Geodon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Agitation (state of anxiety or nervous excitement)
Hallucination (an experience involving the perception of something not present)
Lymphocyte count decreased
Monocyte count increased

10-19:

Blood triglycerides increased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Drug ineffective
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Impaired gastric emptying
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Obesity (having too much body fat)
Type 2 diabetes mellitus

20-29:

Abdominal pain
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Aphthous stomatitis (mouth ulcer)
Arthralgia (joint pain)
Back pain
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Cellulitis (infection under the skin)
Chest discomfort
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

30-39:

Asthenia (weakness)
Blood creatinine increased
Blood urea increased
Ear pain
Eating disorder
Hypersomnia (excessive daytime sleepiness (eds))
Nausea (feeling of having an urge to vomit)
Otitis externa (external ear infection)
Pain in jaw
Peripheral coldness

40-49:

Flatulence (flatus expelled through the anus)
Influenza like illness
Vomiting
Weight decreased
Anxiety
Epistaxis (bleed from the nose)
Panic attack
Tremor (trembling or shaking movements in one or more parts of your body)
Malaise (a feeling of general discomfort or uneasiness)
Colitis pseudomembranous (antibiotic-associated diarrhoea)

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus

60+:

n/a

What are the existing conditions these people have? *

Insomnia (sleeplessness): 4 people, 36.36%
Stress And Anxiety: 3 people, 27.27%
Depression: 2 people, 18.18%
Weight Loss: 1 person, 9.09%
Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 1 person, 9.09%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 9.09%
Psychotic Disorder: 1 person, 9.09%
Pain: 1 person, 9.09%
Nightmares (unpleasant dreams): 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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